منابع مشابه
Breaking The Code
The RSA public key code [1, Chapter 12] is the most widely used encryption technique in modern communication networks, such as the Internet. Its security relies on the fact that no known (classical) computer program can efficiently factor large numbers n, which are the product of two (unknown) primes, p1 and p2. Quantum computers, which currently exist only as mathematical models and have not y...
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The new movie The Imitation Game (to be released after this article goes to press), which recounts the Nazi code-breaking triumph of Alan Turing, appears unlikely to devote much screen time to the mathematician’s foundational contributions to biology. For cinematic reasons this is perhaps understandable, yet the occasion nevertheless provides a fitting opportunity to reflect on his seminal work...
متن کاملBreaking the Code of Amyloid-β Oligomers
Departing from the original postulates that defined various neurodegenerative disorders, accumulating evidence supports a major role for soluble forms of amyloid proteins as initiator toxins in Alzheimer's disease, Parkinson's disease, frontotemporal dementias, and prion diseases. Soluble multimeric assemblies of amyloid- β , tau, α -synuclein, and the prion protein are generally englobed under...
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Just as early molecular biologists made the conceptual leap from the unique structure of DNA—with its precise sequence of nucleotides and complementary strands—to a theoretical and empirical solution to the genetic coding problem, four decades later a new generation of biologists is tackling a similar scientific challenge, this time of even greater complexity. How do DNA sequences specify the c...
متن کاملBreaking the Code of Polyadenylation-Induced Translation
The translation of many maternal mRNAs is regulated by dynamic changes in poly(A) tail length. During maturation of Xenopus oocytes, polyadenylation is mediated by three different cis elements in the 3' untranslated region (UTR) of maternal mRNAs. In this issue, Piqué et al. (2008) explore the interplay of these elements to elucidate a combinatorial code that predicts the timing of polyadenylat...
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ژورنال
عنوان ژورنال: Nature
سال: 1992
ISSN: 0028-0836,1476-4687
DOI: 10.1038/359768d0